Estimation of Molar Absorption Coefficients of HbA1c in Near UV-Vis-SW NIR Light Spectrum 


Vol. 46,  No. 6, pp. 1030-1039, Jun.  2021
10.7840/kics.2021.46.6.1030


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  Abstract

Diabetes is a serious group of diseases that can cause many complicated problems including sudden mortality. Glycated hemoglobin tests are considered as a reliable tool to diagnose diabetes. To estimate amount of glycated hemoglobin (HbA1c) present in Red Blood Cells (RBCs) optically, the molar absorption coefficient of HbA1c is necessary. We calculate the molar absorption coefficient of HbA1c from percent transmittance spectrum of HbA1c dissolved in water and calibrate the values for a range with molar absorption coefficients of glycated hemoglobin at 535nm Green light and 593nm Yellow light references. We estimate the molar absorption coefficient in the range of 300nm to 1100nm, and we have got a characteristic peak of HbA1c at 411nm (5.20×106±1.39 ×106 M-1cm-1) and two more peaks at 540nm (5.63×105±1.51×105 M-1cm-1) and 576nm (4.96×105±1.33×105 M-1cm-1), respectively. The characteristic and secondary peaks found in our study are verified with previous studies and found consistent with them. The calculated molar absorption coefficient from Near UV to shortwave NIR range can enable the way of non-invasive estimation of HbA1c.

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  Cite this article

[IEEE Style]

S. Hossain, T. Kwon, K. Kim, "Estimation of Molar Absorption Coefficients of HbA1c in Near UV-Vis-SW NIR Light Spectrum," The Journal of Korean Institute of Communications and Information Sciences, vol. 46, no. 6, pp. 1030-1039, 2021. DOI: 10.7840/kics.2021.46.6.1030.

[ACM Style]

Shifat Hossain, Tae-Ho Kwon, and Ki-Doo Kim. 2021. Estimation of Molar Absorption Coefficients of HbA1c in Near UV-Vis-SW NIR Light Spectrum. The Journal of Korean Institute of Communications and Information Sciences, 46, 6, (2021), 1030-1039. DOI: 10.7840/kics.2021.46.6.1030.

[KICS Style]

Shifat Hossain, Tae-Ho Kwon, Ki-Doo Kim, "Estimation of Molar Absorption Coefficients of HbA1c in Near UV-Vis-SW NIR Light Spectrum," The Journal of Korean Institute of Communications and Information Sciences, vol. 46, no. 6, pp. 1030-1039, 6. 2021. (https://doi.org/10.7840/kics.2021.46.6.1030)

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pISSN : 1226 - 4717
eISSN : 2287 - 3880